Clinical study points to cytokine storm in H5N1 cases

first_imgSep 11, 2006 (CIDRAP News) – A controlled study of H5N1 influenza patients in Vietnam has provided fresh evidence that explosive viral growth and the resulting cytokine storm, or excessive immune response, account for the often lethal nature of H5N1 disease.The study underlines the importance of early antiviral treatment to stop the viral population explosion. The authors, led by Menno de Jong of the Oxford University Clinical Research Unit in Ho Chi Minh City, Vietnam, suggest that treatment to blunt the late-stage immune response should also be explored.”Our observations point to a central role for high viral burden in the pathogenesis of human H5N1 disease and suggest that timely suppression of viral replication should remain the mainstay of treatment of influenza H5N1,” states the report, published online yesterday by Nature Medicine.The study has also prompted experts to mention the possibility of using intravenous antiviral treatment in an effort to move drugs to the sites of viral activity faster than is possible with oral drugs like oseltamivir (Tamiflu).De Jong’s team conducted virologic and immunologic studies on 18 H5N1 patients and eight patients with ordinary seasonal flu (H3N2 and H1N1 viruses) in 2004 and 2005. Thirteen of the 18 H5N1 patients died of the illness. The H5N1 patients presented for treatment an average of 6 days after the onset of illness—well beyond the recommended 2-day window for starting antiviral treatment. The researchers looked for the virus in samples from the nose, throat, blood, and rectum.Among the virologic findings:H5N1 patients had more viral material (viral RNA) in the throat than in the nose, and they had more viral RNA in the throat than patients with ordinary flu had.H5N1 patients who died had the highest levels of viral RNA.Viral traces were found in blood samples from 9 of the 16 H5N1 patients whose blood was tested; viral RNA in blood was associated with high viral loads in throat specimens.Viral RNA was found in rectal samples from 5 of 7 H5N1 patients, and three of these had diarrhea.The researchers also examined the blood levels of seven cytokines and chemokines—molecular messengers that call various kinds of immune cells into action, triggering inflammation. They found that H5N1 patients had significantly higher levels of 6 out of 7 of these substances than seasonal flu patients had. In addition, levels of four chemokines were particularly high in H5N1 patients who died.”Our observations indicate that high viral load, and the resulting intense inflammatory responses, are central to influenza H5N1 pathogenesis,” the authors write. “The focus of clinical management should be on preventing this intense cytokine response, by early diagnosis and effective antiviral treatment.”They add that the limited effectiveness of antiviral treatment in H5N1 patients when started late may reflect the inability of the drugs to stop the cytokine storm at that point. At that stage, they suggest, treatment to limit or change the immune response “has potential benefits.” But they emphasize that the main focus should be on early diagnosis and antiviral treatment.The central question raised by the study, according to infectious disease expert Michael T. Osterholm, PhD, MPH, is, “At what level of viremia does the cytokine storm get triggered? Once that happens, does it matter what the ongoing level of viral activity happens to be? Once the cytokine storm begins, it’s already too late to have any impact with antivirals.”Osterholm, who is director of the University of Minnesota Center for Infectious Disease Research and Policy, publisher of the CIDRAP Web site, said he doesn’t know of anyone who has tried immunosuppressive or anti-inflammatory drugs to stop the cytokine storm in H5N1 patients.”No one knows what the consequences of that might be,” he said. Reducing the immune response could backfire by allowing the virus to run wild, he suggested.Virologist Frederick G. Hayden, MD, said intravenous administration might improve the effectiveness of antiviral treatment in H5N1 disease, according to a Canadian Press report published yesterday.”A potent parenteral agent . . . is really needed and will give us the ability, I hope, to more rapidly control replication in patients with these kinds of severe infections,” Hayden was quoted as saying.Hayden, of the University of Virginia in Charlottesville, heads a World Health Organization research network that plans to assess various treatment regimens for H5N1 patients, the story said. The report said injectable forms of two antivirals—peramivir and zanamivir (Relenza)—are in development.Osterholm said intravenous drugs move into the system faster, but giving drugs intravenously is harder than giving them orally.  In a flu pandemic, he said, “Will there be IV bags available? If you give a drug that’s only IV, and then you run out of IV sets, you’ve got a problem.”De Jong MD, Simmons CP, Thanh TT, et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nature Med 2006 Sep 10 (early online publication) [Abstract]See also:Nov 16, 2005, CIDRAP News story “Lab study supports idea of ‘cytokine storm’ in H5N1 flu”Oct 11, 2005, CIDRAP News story “Experts cite differences between H5N1 and ordinary flu”Dec 22, 2005, CIDRAP News story “Tamiflu resistance in avian flu victims sparks concern”last_img read more

Thornton and Brogden launch Mayfair Capital Partners

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West Sussex fund drops property manager after 22 years

first_imgAberdeen was selected after the exercise, which saw nine other firms competing for the portfolio.The fund’s property investments, which according to its latest published report are valued at £184m, suffered a capital decline of 4.5% during 2012-13. West Sussex attributed the decline to weaker pricing in the secondary property market.This left the local authority scheme below its strategic allocation, with property only accounting for 7.8% of total assets.Its review of the property portfolio showed the manager had a negative 0.1% return in the last five years, 70 basis points below benchmark, and 4.6% over three years, 1.4 percentage points below.The manager’s target was to provide 1% over the benchmark on a three-year period.West Sussex had given C&WI a discretionary mandate for its property portfolio, which saw the manager purchase a range of assets including supermarkets.The fund recieved close to £8.5m in rental income from the portfolio, its last published report showed.  In the announcement, West Sussex also said its contract with Aberdeen would allow the fund to increase its allocation to property to up to £500m, as it looks to move closer towards its strategic allocation.Before changing its name to LFF Real Estate Partners, C&WI was jointly acquired by La Française, a French property manager, and Forum Partners, as the pair looked to develop their real estate business in Europe.The manager runs a pan-European portfolio and currently has around $1.2bn (€888m) in assets under management. The West Sussex Pension Fund has terminated its 22-year relationship with Cushman & Wakefield Investors (C&WI), transferring its entire property portfolio to Aberdeen Asset Management.The fund, which currently has around £1.9bn (€2.3bn) in assets, has a strategic allocation to property of 10%, which has been managed by C&WI since 1992, according to its annual report.C&WI now trades under La Française Forum Real Estate Partners (LFF Real Estate Partners), following a takeover earlier this year.West Sussex confirmed to IPE its decision to appoint Aberdeen as replacement for C&WI after putting the mandate out to tender in July last year.last_img read more

IMCA state champions awards are new this season from Eibach

first_imgThe Corona, Calif., manufacturer will give $100 certificates to drivers winning IMCA Modified, IMCA Late Model, IMCA Sunoco Stock Car, IMCA Sunoco Hobby Stock, Karl Kustoms Northern SportMod and Smiley’s Racing Products Southern SportMod state crowns.  CORONA, Calif. – Awards for state champions in six IMCA divisions are new this season, courtesy of Eibach Springs.  The 11-year IMCA sponsor had previously given awards in the same divisions, based on regional or national point standings. “For the last 68 years, Eibach has dedicated itself to producing the highest quality, most reliable, consistent racing springs on the market,” Cardey added. “Eibach has withstood the test of time and has continued to win championships in all major forms of racing across the globe year after year. We are a proud American company with a German accent. We are Eibach!”  “This new twist on the Eibach program is something unique and another way to emphasize the accomplishment of winning a state championship,” noted Yoder. “They will issue thousands of dollars in certificates through this program, as well as six complete sets of springs at season’s end. We are excited about these new awards.” Information about Eibach high performance products is available at the website, by calling 800 507-2338 and on Facebook. Eibach awards will be presented during the national banquet in November or mailed beginning the following week from the IMCA home office. “Eibach Springs wanted to come up with a new and exciting program to congratulate a wide variety of racers and (Marketing Director) Kevin (Yoder) and the guys at IMCA came up with the idea of awarding state champions, and we loved it!” Sales Manager David Cardey said. “IMCA has such a vast reach across the country in numerous forms of racing that this was a no brainer. We will be awarding close to $10,000 back to the racers and teams across our great country.” In addition, one randomly selected state champion in each of those divisions receives a set of four springs.last_img read more

Carl Phillip “Phil” Stirn – Brookville

first_imgCarl Phillip “Phil” Stirn, of Brookville, was born on November 10, 1949 a son to Ival and Geraldine McDaniel Kelley.  He married Sally Harper on June 18, 1988 and she preceded him in death on May 7, 2006.  Phil had worked at Sperry and Rice and was a member of the Masonic Lodge in Fairfield.  He loved his grandchildren, his Masonic lodge brothers, and American history – in particular Native American culture, and art expressed through his skillful reproductions.  On Tuesday, September 10, 2019 at the age of 69, Phil died in a car accident.Those surviving who will cherish Phil’s memory include his children, Chris (Cat) Stirn of Decatur, GA, Scott (Kathy) Harper of Brookville, and Clay Heston of Cincinnati; five grandchildren, Tessa, Landon, and Audrey Harper, and Ella and Addie Stirn; three sisters, Kathy Ritzchke of CO, Connie Luttman of NC, and Barbara Guerro of NV; two brothers, Bruce Kelley of Brookville and Donald (Pid) Kelley of Brookville, and several nieces and nephews.  Besides his parents and wife he was preceded in death by a brother, Doug Stirn.Friends may visit with the family on Friday, September 20, 2019 from 10 a.m. until time of service at 12 noon at Cook Rosenberger Funeral Home, 929 Main Street, Brookville.  A graveside service will be held on Friday at 2:30 at Cliff-Hill Cemetery, East 2nd North Street, Versailles, IN 47042.In lieu of flowers memorial donations can be directed to St. Jude Children’s Research Hospital at  To sign the online guestbook or to leave personal memories, please visit  The staff of Cook Rosenberger Funeral Home is honored to care for the family of Phil Stirn.last_img read more

Pochettino demands derby steel

first_imgMauricio Pochettino has experienced the hatred of rival supporters on derby days throughout his career and now he wants his Tottenham players to relish the pressure as he did. Spurs have a poor record at the home of their nearest rivals, with just two wins in the Barclays Premier League era to show for their efforts. But Pochettino has already defied the odds as a manager in a derby – leading unfancied Espanyol to a memorable Primera Division victory at Barcelona in 2009. “When I arrived as Espanyol manager, Espanyol was in last position and Barcelona was top of the table,” he explained. “We go to play in Camp Nou, all people said: ‘okay Espanyol is dead, has no chance.’ – It was 1-2 for us, for 27 years, Espanyol, had never won away. It was a very good start for me.” Pochettino has previously revealed his admiration for Arsenal manager Arsene Wenger but it will be midfielder Mikel Arteta, a man Pochettino calls a ‘brother’, who he is looking forward to seeing at the weekend. “I was captain at PSG, he came from Barcelona,” said the Tottenham head coach. “He was like my brother. I love Mikel Arteta, I know he is in another side, the big sporting enemy but I love Mikel because he is a great person.” Another man ready to put friendship aside is new Spurs midfielder Benjamin Stambouli. The 24-year-old has been getting up to speed on the north London rivalry after moving to White Hart Lane from Montpellier on transfer deadline day and will not be swooning over the former French players who have graced Arsenal in recent years. “I am learning a lot about north London,” he said. “It is a very important game against Arsenal. I know now that they are the enemy. I used to be friends with Olivier Giroud, but now he is no longer my friend – it is finished! “Other players say to me that I will really find out what it is to be a Spurs player when you play against Arsenal. I cannot wait for the game and am ready to play because I want to experience that atmosphere. “For sure I know a lot about Arsenal. A lot of people spoke about them back home because of all the French players who used to play for them. But now I belong to Tottenham and all I want to do is beat them. I won’t be thinking about Thierry Henry or Patrick Vieira – I just want to beat them.” The 42-year-old is enjoying a growing reputation in management having been a combative central defender during his time as a player – with 20 Argentina caps going alongside spells at Newell’s Old Boys, Espanyol and Paris Saint-Germain. Having moved to White Hart Lane from Southampton in the summer, Pochettino will take charge of his first north London derby against fierce rivals Arsenal on Saturday with memories of previous local battles still etched on his mind. Press Association His time with Newell’s certainly provided the scariest of moments when they came up against Rosario – but Pochettino insists he enjoyed the challenge of performing behind enemy lines and wants his players to do the same at the Emirates Stadium. “It was always difficult to arrive (at Rosario’s stadium),” he said. “You needed to arrive with all the (coach) windows closed, everyone lying down on the floor, because it is dangerous. You need to be brave. In this kind of game, you need to be brave to get the victory. Not only outside, but on the pitch. “You also need to be brave to play in Marseille if you play for PSG – when we arrived at the airport it was always with the private security. “It (playing Arsenal) is not another game, it’s impossible it’s another game, I know the feeling of our supporters, we need to relay this feeling on the pitch. “It’s our responsibility to fight in every ball. If we fight the result may arrive for us but we need to fight in the game. Our supporters expect that of us.” Far from being glad to see the back of such days, Pochettino would happily lie on the floor of Tottenham’s team coach as it rolls into Arsenal on Saturday if it meant getting the best from his players. “I would like to!,” he said when asked if he expected to be ducking for cover at the Emirates. “It’s my habit, it’s not strange for me. I’m more strong with hostiles situation, I like it.” last_img read more

Boys’ soccer roundup

first_imgAustin Mason of the Bucksport Golden Bucks pushes the ball up the fi eld as he is pursued by Tyler Bunker of the Sumner Tigers. Trailing the play are Justin Burgess of the Golden Bucks and Baramee Janla of the Tigers. Janla scored three goals to lead Sumner to a 5-0 win.ELLSWORTH — With wins in their first three games, the Ellsworth Eagle boys were ranked third in the Eastern Maine Class B soccer standings published this week by the Maine Principals’ Association. Hugh BowdenExecutive EditorHugh writes editorials, covers Hancock County sports and helps out where needed in The American’s editorial department. When he’s not on the sidelines, he enjoys playing jazz and tennis. Bio Like he did in the ’60s, Noel Paul Stookey sings out in troubling times – December 27, 2017 The Eagles notched a pair of 2-1 wins over the John Bapst Crusaders and the Old Town Coyotes and trailed only Winslow and Presque Isle in Wednesday’s rankings.With a record of 1-1-1, the George Stevens Academy Eagles were ranked sixth in Class C, with the 1-2-0 Sumner Tigers in 11th place.This is placeholder textThis is placeholder textThe Mount Desert Island Trojans in Class B, the Bucksport Golden Bucks in Class C and the Deer Isle-Stonington Mariners in Class D are still looking for their first wins of the season.In action this week:GSA 2, Washington Academy 2The GSA Eagles battled the Washington Academy Raiders to a 2-2 tie on Thursday in East Machias.Ellsworth 2, John Bapst 1A pair of early goals by Jeff Weeks and Brady White proved to be enough as the Eagles squeaked past the John Bapst Crusaders 2-1 on Friday in Bangor.A second-half penalty kick by Matt Richards was the lone goal for the Crusaders as goalkeeper Nick Bagley made four saves on seven shots for the Eagles.Bach Nguyen had 10 stops on 15 shots in goal for John Bapst.Sumner 5, Bucksport 0Baramee Janla scored three goals to lead the Tigers to a 5-0 shutout win over the Golden Bucks on Thursday in Sullivan.Maverick Eklund and Darren Turner also scored first-half goals for the Tigers in the win.Ellsworth 2, Old Town 1A goal by Jack Weeks lifted the Eagles to their third consecutive win on Saturday in Old Town.Weeks snapped a 1-1 tie when he found the net on a shot with just over 10 minutes gone in the second half.Alex Braley had put Ellsworth in front, but Niko Knapp punched a rebound into the net for the equalizer in the first half.Goalkeepers Bruce St. Peter and Nick Bagley combined for eight saves for the Eagles, and Austin Sheehan made 11 stops for the Coyotes.Presque Isle 1, MDI 0With the game less than two minutes old, Ben Nickerson scored the lone goal to give the Presque Isle Wildcats a 1-0 win over the Trojans on Saturday in Presque Isle.Simon Hulbert made 11 saves on 15 shots in goal for MDI, and Andrew Patterson had three saves on five shots for the Wildcats.Schenck 3, DI-Stonington 0The Schenck Wolverines got a pair of goals from Ryan Leavitt and another from Brandon Danforth as they downed the Mariners 3-0 on Saturday in Deer Isle.Ethan Shepard made 22 saves on 30 shots in goal for the Mariners, and Justin Thompson had nine saves on 10 shots for the Wolverines. Is this the kind of government we deserve? – July 10, 2017 Latest Posts Latest posts by Hugh Bowden (see all) GSA surges in 4th to win Northern Maine title – February 26, 2017last_img read more

State tennis players back to court at Chachal Tennis complex

first_imgOUR SPORTS REPORTERGUWAHATI: Sports arenas in the city are active again. National-level tennis players of the State returned to the court today for the first time after the lockdown was imposed to combat COVID-19. As a part of the decision of the All Assam Tennis Association (AATA), the national level players started training at the Chachal Tennis complex this afternoon. Initially, the AATA selected 18 players for the beginning of training and 10 of them turned up on day one. Talking to The Sentinel, the secretary of the AATA Ankush Dutta said, “As per the government advisory, only national level players have been allowed in the training. We are also following the standard operating procedure (SOP) sent by the All India Tennis Association.” He also added: “The players started their practice today maintaining social distance and coaches were advised to monitor so that all the guidelines are strictly followed.” It may be mentioned here that sports activities have come to standstill because of the lockdown imposed in March. The athletes were forced to stay at home for nearly two months and now they are raring to go.last_img read more

George H.W. Bush remembered for connection to sports, especially in Houston

first_imgFormer President George H.W. Bush, who died Friday at age 94, was a dedicated sports fan who took a keen interest in the teams in the Houston area, where the Connecticut transplant resided for decades. The Astros drew much of that interest, not a great surprise given that Bush played baseball while attending Yale.As Americans were processing the news of his death, Houston’s teams and schools (and even Texas’ governor) were hailing the nation’s 41st chief executive/first fan: MORE: Notable sports deaths of 2018I was honored to know President George H.W. Bush. His love for our country and all things American made a lasting impression on me. He treated people with respect and always put family first. These are life lessons we should all emulate.— Reid Ryan (@robertreidryan) December 1, 2018Statement from @TilmanJFertitta and family on the passing of former President George H.W. Bush.— Houston Rockets (@HoustonRockets) December 1, 2018President Bush gave us a memory we will cherish forever… an amazing man who will be missed. #RIP41— Texas A&M Baseball (@AggieBaseball) December 1, 2018We were blessed to have President Bush as a friend of the program. He will always have a special place in our hearts.#RIP41— Texas A&M Soccer (@AggieSoccer) December 1, 2018One thing President George H. W. Bush loved was Texas A&M football. This was at a Texas—Texas A&M game in college station. He will always be cherished for his love of Texas traditions.— Greg Abbott (@GregAbbott_TX) December 1, 2018We are sorry to hear about the passing of President George H.W. Bush. We fondly remember his visit with our USA Women’s National Team during the 2008 Olympic Games in Beijing. #RIP41— USA Water Polo (@USAWP) December 1, 2018last_img read more

Thurston County Economic Development Council Receives $189,000 to Help Local Companies…

first_imgSubmitted by the Office of Congressmen Denny Heck (WA-10) Congressmen Denny Heck and SBA Administrator Maria Contreras-SweetPhoto Credit Nate GowdyToday, Representative Denny Heck (WA-10) announced the Thurston County Economic Development Council Business Resource Center was selected to receive a U.S.  Small Business Administration grant of $189,000 to provide small businesses the opportunity to expand in order to support local jobs and grow the local economy.The grant, provided through SBA’s ScaleUp Initiative, targets traditionally underserved business owners, including veterans, women, tribal members, and minorities. The Thurston ScaleUp plan works together with South Puget Sound Community College, SBA, and other partners to help these business owners grow their operations.Congressman Denny Heck of Washington’s 10th Congressional District congratulated Thurston EDC on their successful grant request:“As a small business owner, I know the challenges that these business owners face every day,” Heck said. “And I’m not saying every business day. Every single day, weekends and holidays included, they are working hard to expand their operations and create jobs for our community.  This grant honors their hard work behind-the-scenes and encourages them to continue to pursue their great ideas and long-term business goals with even more energy.”“The Small Business Administration appreciates Congressman Heck’s commitment to small businesses in Thurston County and his pragmatism in applying our programs to a promising business community,” SBA Regional Administrator Calvin Goings said. “We are looking forward to helping Thurston County’s small businesses reach the next level and expand their capabilities within their respective industries.”Congressmen Denny Heck announced Thurston County Economic Development Council Business Resource Center was selected to receive a U.S. Small Business Administration grant of $189,000.“The ScaleUp Initiative is a fantastic opportunity for Thurston County’s small businesses to grow to the next level of success,” said Michael Cade, Executive Director of the Thurston Economic Development Council. “Through our partnership with SPSCC at the new Center for Business & Innovation, we will be able to provide all the technical services businesses need to move to the next level. This grant will give us the leverage needed to ensure companies in our community that are on a high-growth trajectory have the tools needed to sustain that growth, contributing to the health of our local economy, and providing high-value jobs.”On July 13, 2015, Congressman Heck wrote to SBA Administrator Maria Contreras-Sweet to express his strong support of ScaleUp Thurston and their proposal.“The Thurston County EDC and BRC are vital to Thurston County’s business community; with an established track record of providing effective technical assistance to small and growing business,” Heck wrote. “ScaleUp Thurston would allow the Thurston County EDC and BRC to provide new services to the business community as well to improve their existing services.”On February 18, 2015, Congressman Heck hosted Administrator Contreras-Sweet in the 10th Congressional District for a small business tour and round table. Facebook35Tweet0Pin0last_img read more